We are happy to announce that our newest paper titled 'Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior' is finally online!
Associative learning is a procedure in which a biologically/behavioralyl
relevant stimulus (unconditioned, affective signal, US; e.g. foot-shock)
is paired with a previously neutral stimulus (conditioned stimulus, CS;
e.g. tone). Based on the current concept, the CS and US association
takes place in the lateral amygdala. However, there has been no scientific
proof for this association within the amygdala, nor for the source of
these signals. We identified a thalamic population which
receives multimodal brainstem inputs and conveys CS-US associated cues to
the lateral amygdala. Our findings, published in Nature Neuroscience on
April 13, 2020, highlight that the fast associative and plastic
environmental signal originating from lateral thalamic regions is
essential for the formation and recall of associative fear memory.